Ngo, T.-E., Ecker, A., Ryu, B., Guild, A., Remmel, A., Boudreau, P. D., Alexander, K. L., Naman, C. B., Glukhov, E., Avalon, N. E., Shende, V. V., Thomas, L., Dahesh, S., Nizet, V., Gerwick, L., & Gerwick, W. H. (2024). Structure and Biosynthesis of Hectoramide B, a Linear Depsipeptide from Marine Cyanobacterium Moorena producens JHB Discovered via Coculture with Candida albicans. ACS Chemical Biology, 19(3), 619–628.
Gahl, M., Kim, H. W., Glukhov, E., Gerwick, W. H., & Cottrell, G. W. (2024). PECAN Predicts Patterns of Cancer Cell Cytostatic Activity of Natural Products Using Deep Learning. Journal of Natural Products, acs.jnatprod.3c00879.
Zuffa, S., Schmid, R., Bauermeister, A., P. Gomes, P. W., Caraballo-Rodriguez, A. M., El Abiead, Y., Aron, A. T., Gentry, E. C., Zemlin, J., Meehan, M. J., Avalon, N. E., Cichewicz, R. H., Buzun, E., Terrazas, M. C., Hsu, C.-Y., Oles, R., Ayala, A. V., Zhao, J., Chu, H., … Dorrestein, P. C. (2024). microbeMASST: a taxonomically informed mass spectrometry search tool for microbial metabolomics data. Nature Microbiology, 9(2), 336–345.
Almaliti, J., Alhindy, M., Yoon, M. C., Hook, V., Molinski, T. F., O’Donoghue, A. J., & Gerwick, W. H. (2024). Orthogonal Deprotection Strategy of Fmoc Provides Improved Synthesis of Sensitive Peptides: Application to Z-Arg-Lys-AOMK. ACS Omega, acsomega.3c08629.
Bittremieux, W., Avalon, N. E., Thomas, S. P., Kakhkhorov, S. A., Aksenov, A. A., Gomes, P. W. P., Aceves, C. M., Caraballo-Rodríguez, A. M., Gauglitz, J. M., Gerwick, W. H., Huan, T., Jarmusch, A. K., Kaddurah-Daouk, R. F., Kang, K. B., Kim, H. W., Kondić, T., Mannochio-Russo, H., Meehan, M. J., Melnik, A. V., … Dorrestein, P. C. (2023). Open access repository-scale propagated nearest neighbor suspect spectral library for untargeted metabolomics. Nature Communications, 14(1), 8488.
Esposito, G., Glukhov, E., Gerwick, W. H., Medio, G., Teta, R., Lega, M., & Costantino, V. (2023). Lake Avernus Has Turned Red: Bioindicator Monitoring Unveils the Secrets of “Gates of Hades.” Toxins, 15(12), 698.
Ternon, E., Carter, M. L., Cancelada, L., Lampe, R. H., Allen, A. E., Anderson, C. R., Prather, K. A., & Gerwick, W. H. (2023). Yessotoxin production and aerosolization during the unprecedented red tide of 2020 in southern California. Elem Sci Anth, 11(1), 00021.
Bennett, J. M., Ward, K. E., Muir, R. K., Kabeche, S., Yoo, E., Yeo, T., Lam, G., Zhang, H., Almaliti, J., Berger, G., Faucher, F. F., Lin, G., Gerwick, W. H., Yeh, E., Fidock, D. A., & Bogyo, M. (2023). Covalent Macrocyclic Proteasome Inhibitors Mitigate Resistance in Plasmodium falciparum. ACS Infectious Diseases, 9(10), 2036–2047.
Lukowski, A. L., Hubert, F. M., Ngo, T.-E., Avalon, N. E., Gerwick, W. H., & Moore, B. S. (2023). Enzymatic Halogenation of Terminal Alkynes. Journal of the American Chemical Society, 145(34), 18716–18721.
Kim, H. W., Zhang, C., Reher, R., Wang, M., Alexander, K. L., Nothias, L.-F., Han, Y. K., Shin, H., Lee, K. Y., Lee, K. H., Kim, M. J., Dorrestein, P. C., Gerwick, W. H., & Cottrell, G. W. (2023). DeepSAT: Learning Molecular Structures from Nuclear Magnetic Resonance Data. Journal of Cheminformatics, 15(1), 71.
Boyarko, B., Podvin, S., Greenberg, B., Momper, J. D., Huang, Y., Gerwick, W. H., Bang, A. G., Quinti, L., Griciuc, A., Kim, D. Y., Tanzi, R. E., Feldman, H. H., & Hook, V. (2023). Evaluation of bumetanide as a potential therapeutic agent for Alzheimer’s disease. Frontiers in Pharmacology, 14, 1190402.
Almaliti, J., & Gerwick, W. H. (2023). Methods in marine natural product drug discovery: what’s new? Expert Opinion on Drug Discovery, 18(7), 687–691.
Almaliti, J., Fajtová, P., Calla, J., LaMonte, G. M., Feng, M., Rocamora, F., Ottilie, S., Glukhov, E., Boura, E., Suhandynata, R. T., Momper, J. D., Gilson, M. K., Winzeler, E. A., Gerwick, W. H., & O’Donoghue, A. J. (2023). Development of Potent and Highly Selective Epoxyketone‐Based Plasmodium Proteasome Inhibitors. Chemistry – A European Journal, 29(20), e202203958.
Shrestha, S. K., Min, K. H., Kim, S. W., Kim, H., Gerwick, W. H., & Soh, Y. (2023). Kalkitoxin: A Potent Suppressor of Distant Breast Cancer Metastasis. International Journal of Molecular Sciences, 24(2), 1207.
Mullowney, M. W., Duncan, K. R., Elsayed, S. S., Garg, N., Van Der Hooft, J. J. J., Martin, N. I., Meijer, D., Terlouw, B. R., Biermann, F., Blin, K., Durairaj, J., Gorostiola González, M., Helfrich, E. J. N., Huber, F., Leopold-Messer, S., Rajan, K., De Rond, T., Van Santen, J. A., Sorokina, M., … Medema, M. H. (2023). Artificial intelligence for natural product drug discovery. Nature Reviews Drug Discovery, 22(11), 895–916.
Deni, I., Stokes, B. H., Ward, K. E., Fairhurst, K. J., Pasaje, C. F. A., Yeo, T., Akbar, S., Park, H., Muir, R., Bick, D. S., Zhan, W., Zhang, H., Liu, Y. J., Ng, C. L., Kirkman, L. A., Almaliti, J., Gould, A. E., Duffey, M., O’Donoghue, A. J., … Fidock, D. A. (2023). Mitigating the risk of antimalarial resistance via covalent dual-subunit inhibition of the Plasmodium proteasome. Cell Chemical Biology, 30(5), 470-485.e6.
Ternon, E., Thomas, O. P., Lemée, R., & Gerwick, W. H. (2022). Rapid Biotic and Abiotic Transformation of Toxins produced by Ostreopsis. cf. ovata. Marine Drugs, 20(12), 748.
Leão, T. F., Wang, M., da Silva, R., Gurevich, A., Bauermeister, A., Gomes, P. W. P., Brejnrod, A., Glukhov, E., Aron, A. T., Louwen, J. J. R., Kim, H. W., Reher, R., Fiore, M. F., van der Hooft, J. J. J., Gerwick, L., Gerwick, W. H., Bandeira, N., & Dorrestein, P. C. (2022). NPOmix: A machine learning classifier to connect mass spectrometry fragmentation data to biosynthetic gene clusters. PNAS Nexus, 1(5), pgac257.
Reher, R., Aron, A. T., Fajtová, P., Stincone, P., Wagner, B., Pérez-Lorente, A. I., Liu, C., Shalom, I. Y. B., Bittremieux, W., Wang, M., Jeong, K., Matos-Hernandez, M. L., Alexander, K. L., Caro-Diaz, E. J., Naman, C. B., Scanlan, J. H. W., Hochban, P. M. M., Diederich, W. E., Molina-Santiago, C., … Petras, D. (2022). Native metabolomics identifies the rivulariapeptolide family of protease inhibitors. Nature Communications, 13(1), 4619.
Phan, V. V., Mosier, C., Yoon, M. C., Glukhov, E., Caffrey, C. R., O’Donoghue, A. J., Gerwick, W. H., & Hook, V. (2022). Discovery of pH-Selective Marine and Plant Natural Product Inhibitors of Cathepsin B Revealed by Screening at Acidic and Neutral pH Conditions. ACS Omega, 7(29), 25346–25352.
Taton, A., Rohrer, S., Diaz, B., Reher, R., Caraballo Rodriguez, A. M., Pierce, M. L., Dorrestein, P. C., Gerwick, L., Gerwick, W. H., & Golden, J. W. (2022). Heterologous Expression in Anabaena of the Columbamide Pathway from the Cyanobacterium Moorena bouillonii and Production of New Analogs. ACS Chemical Biology, 17(7), 1910–1923.
He, Y., Suyama, T. L., Kim, H., Glukhov, E., & Gerwick, W. H. (2022). Discovery of Novel Tyrosinase Inhibitors From Marine Cyanobacteria. Frontiers in Microbiology, 13, 912621.
Li, F.-L., Fu, V., Liu, G., Tang, T., Konradi, A. W., Peng, X., Kemper, E., Cravatt, B. F., Franklin, J. M., Wu, Z., Mayfield, J., Dixon, J. E., Gerwick, W. H., & Guan, K.-L. (2022). Hippo pathway regulation by phosphatidylinositol transfer protein and phosphoinositides. Nature Chemical Biology.
Wang, Y., Glukhov, E., He, Y. F., Liu, Y. Y., Zhou, L. J., Ma, X. X., Hu, X. Q., Hong, P. Z., Gerwick, W. H., & Zhang, Y. (2022). Secondary metabolite variation and bioactivities of two marine aspergillus strains in static co-culture investigated by molecular network analysis and multiple database mining based on LC-PDA-MS/MS. Antibiotics-Basel, 11(4), 26.
Da Silva, E. B., Sharma, V., Hernandez-Alvarez, L., Tang, A. H., Stoye, A., O’Donoghue, A. J., Gerwick, W. H., Payne, R. J., McKerrow, J. H., & Podust, L. M. (2022). Intramolecular interactions enhance the potency of gallinamide A analogues against Trypanosoma cruzi. Journal of Medicinal Chemistry, 65(5), 4255–4269.
Mehrotra, S., Pierce, M. L., Cao, Z. Y., Jabba, S. V., Gerwick, W. H., & Murray, T. F. (2022). Antillatoxin-stimulated neurite outgrowth involves the brain-derived neurotrophic factor (BDNF)-tropomyosin related kinase B (TrkB) aignaling pathway br. Journal of Natural Products, 85(3), 562–571.
Ashhurst, A. S., Tang, A. H., Fajtova, P., Yoon, M. C., Aggarwal, A., Bedding, M. J., Stoye, A., Beretta, L., Pwee, D., Drelich, A., Skinner, D., Li, L. F., Meek, T. D., McKerrow, J. H., Hook, V., Tseng, C. T., Larance, M., Turville, S., Gerwick, W. H., … Payne, R. J. (2022). Potent Anti-SARS-CoV-2 Activity by the Natural Product Gallinamide A and Analogues via Inhibition of Cathepsin L. Journal of Medicinal Chemistry, 65(4), 2956–2970.
Yoon, M. C., Christy, M. P., Phan, V. V., Gerwick, W. H., Hook, G., O’Donoghue, A. J., & Hook, V. (2022). Molecular features of CA-074 pH-dependent inhibition of Cathepsin B. Biochemistry, 61(4), 228–238.
Ottilie, S., Luth, M. R., Hellemann, E., Goldgof, G. M., Vigil, E., Kumar, P., Cheung, A. L., Song, M., Godinez-Macias, K. P., Carolino, K., Yang, J., Lopez, G., Abraham, M., Tarsio, M., LeBlanc, E., Whitesell, L., Schenken, J., Gunawan, F., Patel, R., … Winzeler, E. A. (2022). Adaptive laboratory evolution in S. cerevisiae highlights role of transcription factors in fungal xenobiotic resistance. Communications Biology, 5(1), 14.
Kim, G. J., Mascuch, S. J., Mevers, E., Boudreau, P. D., Gerwick, W. H., & Choi, H. (2022). Luquilloamides, cytotoxic lipopeptides from a puerto rican collection of the filamentous marine cyanobacterium Oscillatoria sp. Journal of Organic Chemistry, 13.
Kim, H. W., Zhang, C., Cottrell, G. W., & Gerwick, W. H. (2021). SMART-Miner: A convolutional neural network-based metabolite identification from H-1-C-13 HSQC spectra. Magnetic Resonance in Chemistry, 6.
Kim, H. W., Wang, M. X., Leber, C. A., Nothias, L. F., Reher, R., Kang, K. B., van der Hooft, J. J. J., Dorrestein, P. C., Gerwick, W. H., & Cottrell, G. W. (2021). NPClassifier: A Deep Neural Network-Based Structural Classification Tool for Natural Products. Journal of Natural Products, 84(11), 2795–2807.
Almaliti, J., Fajtova, P., O’Donoghue, A. J., AlHindy, M., & Gerwick, W. H. (2021). Improved scalable synthesis of clinical candidate KZR-616, a selective immunoproteasome inhibitor. Chemistryselect, 6(44), 12461–12465.
Yoon, M. C., Solania, A., Jiang, Z. Z., Christy, M. P., Podvin, S., Mosier, C., Lietz, C. B., Ito, G., Gerwick, W. H., Wolan, D. W., Hook, G., O’Donoghue, A. J., & Hook, V. (2021). Selective neutral pH Inhibitor of Cathepsin B designed based on cleavage preferences at cytosolic and lysosomal pH conditions. Acs Chemical Biology, 16(9), 1628–1643.
Iwasaki, A., Teranuma, K., Kurisawa, N., Rahmawati, Y., Jeelani, G., Nozaki, T., Gerwick, W. H., & Suenaga, K. (2021). First total synthesis and structure-activity relationship of iheyamide A, an antitrypanosomal linear peptide isolated from a Dapis sp. Marine cyanobacterium. Journal of Natural Products, 84(9), 2587–2593.
Demirkiran, O., Almaliti, J., Leao, T., Navarro, G., Byrum, T., Valeriote, F. A., Gerwick, L., & Gerwick, W. H. (2021). Portobelamides A and B and Caciqueamide, Cytotoxic Peptidic Natural Products from a Caldora sp. Marine Cyanobacterium. Journal of Natural Products, 84(8), 2081–2093.
Kim, H. W., Jeon, J. B., Zhang, M., Cho, H. M., Ryu, B., Lee, B. W., Gerwick, W. H., & Oh, W. K. (2021). SIRT1 Activation Enhancing 8,3 ’-Neolignans from the Twigs of Corylopsis coreana Uyeki. Plants-Basel, 10(8), 12.
Taylor, K. S., Zhang, C., Glukhov, E., Gerwick, W. H., & Suyama, T. L. (2021). Total synthesis of laucysteinamide A, a monomeric congener of somocystinamide A. Journal of Natural Products, 84(3), 865–870.
Li, L., Yang, M., Shrestha, S. K., Kim, H., Gerwick, W. H., & Soh, Y. (2021). Kalkitoxin reduces osteoclast formation and resorption and protects against inflammatory bone loss. International Journal of Molecular Sciences, 22(5).
Leber, C. A., Reyes, A. J., Biggs, J. S., & Gerwick, W. H. (2021). Cyanobacteria-shrimp colonies in the Mariana Islands. Aquatic Ecology.
Christy, M. P., Uekusa, Y., Gerwick, L., & Gerwick, W. H. (2021). Natural products with potential to treat RNA virus pathogens including SARS-CoV-2. Journal of Natural Products, 84(1), 161–182.
Leao, T., Wang, M. X., Moss, N., da Silva, R., Sanders, J., Nurk, S., Gurevich, A., Humphrey, G., Reher, R., Zhu, Q. Y., Belda-Ferre, P., Glukhov, E., Whitner, S., Alexander, K. L., Rex, R., Pevzner, P., Dorrestein, P. C., Knight, R., Bandeira, N., … Gerwick, L. (2021). A multi-omics characterization of the natural product potential of tropical filamentous marine cyanobacteria. Marine Drugs, 19(1).
Taton, A., Ecker, A., Diaz, B., Moss, N. A., Anderson, B., Reher, R., Leao, T. F., Simkovsky, R., Dorrestein, P. C., Gerwick, L., Gerwick, W. H., & Golden, J. W. (2020). Heterologous expression of cryptomaldamide in a cyanobacterial host. Acs Synthetic Biology, 9(12), 3364–3376.
Li, Y. Y., Naman, C. B., Alexander, K. L., Guan, H. S., & Gerwick, W. H. (2020). The chemistry, biochemistry and pharmacology of marine natural products from Leptolyngbya, a chemically endowed genus of cyanobacteria. Marine Drugs, 18(10).
Leber, C. A., Naman, C. B., Keller, L., Almaliti, J., Caro-Diaz, E. J. E., Glukhov, E., Joseph, V., Sajeevan, T. P., Reyes, A. J., Biggs, J. S., Li, T., Yuan, Y., He, S., Yan, X. J., & Gerwick, W. H. (2020). Applying a chemogeographic strategy for natural product discovery from the marine cyanobacterium Moorena bouillonii. Marine Drugs, 18(10).
Yang, J. M., Liu, Y. Y., Yang, W. C., Ma, X. X., Nie, Y. Y., Glukhov, E., Gerwick, L., Gerwick, W. H., Lei, X. L., & Zhang, Y. (2020). An anti-inflammatory isoflavone from soybean inoculated with a marine fungusAspergillus terreusC23-3. Bioscience Biotechnology and Biochemistry, 84(8), 1546–1553.
Wold, C. W., Gerwick, W. H., Wangensteen, H., & Inngjerdingen, K. T. (2020). Bioactive triterpenoids and water-soluble melanin from Inonotus obliquus (Chaga) with immunomodulatory activity. Journal of Functional Foods, 71.
Ndukwe, I. E., Wang, X., Lam, N. Y. S., Ermanis, K., Alexander, K. L., Bertin, M. J., Martin, G. E., Muir, G., Paterson, I., Britton, R., Goodman, J. M., Helfrich, E. J. N., Piel, J., Gerwick, W. H., & Williamson, R. T. (2020). Synergism of anisotropic and computational NMR methods reveals the likely configuration of phormidolide A. Chemical Communications, 56(55), 7565–7568.
Sequeira, E., Pierce, M. L., Akasheh, D., Sellers, S., Gerwick, W. H., Baden, D. G., & Murray, T. F. (2020). Epicortical Brevetoxin Treatment Promotes Neural Repair and Functional Recovery after Ischemic Stroke. Marine Drugs, 18(7).
Keller, L., Siqueira-Neto, J. L., Souza, J. M., Eribez, K., LaMonte, G. M., Smith, J. E., & Gerwick, W. H. (2020). Palstimolide A: A complex polyhydroxy macrolide with antiparasitic activity. Molecules, 25(7).