Publications – Zotero

Yoon, M. C., Solania, A., Jiang, Z. Z., Christy, M. P., Podvin, S., Mosier, C., Lietz, C. B., Ito, G., Gerwick, W. H., Wolan, D. W., Hook, G., O’Donoghue, A. J., & Hook, V. (2021). Selective neutral pH Inhibitor of Cathepsin B designed based on cleavage preferences at cytosolic and lysosomal pH conditions. Acs Chemical Biology, 16(9), 1628–1643.
Iwasaki, A., Teranuma, K., Kurisawa, N., Rahmawati, Y., Jeelani, G., Nozaki, T., Gerwick, W. H., & Suenaga, K. (2021). First total synthesis and structure-activity relationship of iheyamide A, an antitrypanosomal linear peptide isolated from a Dapis sp. Marine cyanobacterium. Journal of Natural Products, 84(9), 2587–2593.
Kim, H. W., Jeon, J. B., Zhang, M., Cho, H. M., Ryu, B., Lee, B. W., Gerwick, W. H., & Oh, W. K. (2021). SIRT1 Activation Enhancing 8,3 ’-Neolignans from the Twigs of Corylopsis coreana Uyeki. Plants-Basel, 10(8), 12.
Demirkiran, O., Almaliti, J., Leao, T., Navarro, G., Byrum, T., Valeriote, F. A., Gerwick, L., & Gerwick, W. H. (2021). Portobelamides A and B and Caciqueamide, Cytotoxic Peptidic Natural Products from a Caldora sp. Marine Cyanobacterium. Journal of Natural Products, 84(8), 2081–2093.
Taylor, K. S., Zhang, C., Glukhov, E., Gerwick, W. H., & Suyama, T. L. (2021). Total synthesis of laucysteinamide A, a monomeric congener of somocystinamide A. Journal of Natural Products, 84(3), 865–870.
Li, L., Yang, M., Shrestha, S. K., Kim, H., Gerwick, W. H., & Soh, Y. (2021). Kalkitoxin reduces osteoclast formation and resorption and protects against inflammatory bone loss. International Journal of Molecular Sciences, 22(5).
Leber, C. A., Reyes, A. J., Biggs, J. S., & Gerwick, W. H. (2021). Cyanobacteria-shrimp colonies in the Mariana Islands. Aquatic Ecology.
Christy, M. P., Uekusa, Y., Gerwick, L., & Gerwick, W. H. (2021). Natural products with potential to treat RNA virus pathogens including SARS-CoV-2. Journal of Natural Products, 84(1), 161–182.
Leao, T., Wang, M. X., Moss, N., da Silva, R., Sanders, J., Nurk, S., Gurevich, A., Humphrey, G., Reher, R., Zhu, Q. Y., Belda-Ferre, P., Glukhov, E., Whitner, S., Alexander, K. L., Rex, R., Pevzner, P., Dorrestein, P. C., Knight, R., Bandeira, N., … Gerwick, L. (2021). A multi-omics characterization of the natural product potential of tropical filamentous marine cyanobacteria. Marine Drugs, 19(1).
Taton, A., Ecker, A., Diaz, B., Moss, N. A., Anderson, B., Reher, R., Leao, T. F., Simkovsky, R., Dorrestein, P. C., Gerwick, L., Gerwick, W. H., & Golden, J. W. (2020). Heterologous expression of cryptomaldamide in a cyanobacterial host. Acs Synthetic Biology, 9(12), 3364–3376.
Li, Y. Y., Naman, C. B., Alexander, K. L., Guan, H. S., & Gerwick, W. H. (2020). The chemistry, biochemistry and pharmacology of marine natural products from Leptolyngbya, a chemically endowed genus of cyanobacteria. Marine Drugs, 18(10).
Leber, C. A., Naman, C. B., Keller, L., Almaliti, J., Caro-Diaz, E. J. E., Glukhov, E., Joseph, V., Sajeevan, T. P., Reyes, A. J., Biggs, J. S., Li, T., Yuan, Y., He, S., Yan, X. J., & Gerwick, W. H. (2020). Applying a chemogeographic strategy for natural product discovery from the marine cyanobacterium Moorena bouillonii. Marine Drugs, 18(10).
Wold, C. W., Gerwick, W. H., Wangensteen, H., & Inngjerdingen, K. T. (2020). Bioactive triterpenoids and water-soluble melanin from Inonotus obliquus (Chaga) with immunomodulatory activity. Journal of Functional Foods, 71.
Yang, J. M., Liu, Y. Y., Yang, W. C., Ma, X. X., Nie, Y. Y., Glukhov, E., Gerwick, L., Gerwick, W. H., Lei, X. L., & Zhang, Y. (2020). An anti-inflammatory isoflavone from soybean inoculated with a marine fungusAspergillus terreusC23-3. Bioscience Biotechnology and Biochemistry, 84(8), 1546–1553.
Ndukwe, I. E., Wang, X., Lam, N. Y. S., Ermanis, K., Alexander, K. L., Bertin, M. J., Martin, G. E., Muir, G., Paterson, I., Britton, R., Goodman, J. M., Helfrich, E. J. N., Piel, J., Gerwick, W. H., & Williamson, R. T. (2020). Synergism of anisotropic and computational NMR methods reveals the likely configuration of phormidolide A. Chemical Communications, 56(55), 7565–7568.
Sequeira, E., Pierce, M. L., Akasheh, D., Sellers, S., Gerwick, W. H., Baden, D. G., & Murray, T. F. (2020). Epicortical Brevetoxin Treatment Promotes Neural Repair and Functional Recovery after Ischemic Stroke. Marine Drugs, 18(7).
Keller, L., Siqueira-Neto, J. L., Souza, J. M., Eribez, K., LaMonte, G. M., Smith, J. E., & Gerwick, W. H. (2020). Palstimolide A: A complex polyhydroxy macrolide with antiparasitic activity. Molecules, 25(7).
Keller, L., Canuto, K. M., Liu, C. X., Suzuki, B. M., Almaliti, J., Sikandar, A., Naman, C. B., Glukhov, E., Luo, D. M., Duggan, B. M., Luesch, H., Koehnke, J., O’Donoghue, A. J., & Gerwick, W. H. (2020). Tutuilamides A-C: Vinyl-chloride-containing cyclodepsipeptides from marine cyanobacteria with potent elastase inhibitory properties. Acs Chemical Biology, 15(3), 751–757.
Uranga, C. C., Arroyo, P., Duggan, B. M., Gerwick, W. H., & Edlunda, A. (2020). Commensal oral rothia mucilaginosa produces enterobactin, a metal-chelating siderophore. MSystems, 5(2).
Li, Y. Y., Yu, H. B., Zhang, Y., Leao, T., Glukhov, E., Pierce, M. L., Zhang, C., Kim, H., Mao, H. H., Fang, F., Cottrell, G. W., Murray, T. F., Gerwick, L., Guan, H. S., & Gerwick, W. H. (2020). Pagoamide A, a cyclic depsipeptide isolated from a cultured marine chlorophyte, Derbesia sp., using MS/MS-based molecular networking. Journal of Natural Products, 83(3), 617–625.
Reher, R., Kim, H. W., Zhang, C., Mao, H. H., Wang, M. X., Nothias, L. F., Caraballo-Rodriguez, A. M., Glukhov, E., Teke, B., Leao, T., Alexander, K. L., Duggan, B. M., Van Everbroeck, E. L., Dorrestein, P. C., Cottrell, G. W., & Gerwick, W. H. (2020). A convolutional neural network-based approach for the rapid annotation of molecularly diverse natural products. Journal of the American Chemical Society, 142(9), 4114–4120.
Skiba, M. A., Tran, C. L., Dan, Q. Y., Sikkema, A. P., Klaver, Z., Gerwick, W. H., Sherman, D. H., & Smith, J. L. (2020). Repurposing the GNAT fold in the initiation of polyketide biosynthesis. Structure, 28(1), 63-+.
Cao, L., Gurevich, A., Alexander, K. L., Naman, C. B., Leao, T., Glukhov, E., Luzzatto-Knaan, T., Vargas, F., Quinn, R., Bouslimani, A., Nothias, L. F., Singh, N. K., Sanders, J. G., Benitez, R. A. S., Thompson, L. R., Hamid, M. N., Morton, J. T., Mikheenko, A., Shlemov, A., … Mohimani, H. (2019). MetaMiner: A scalable peptidogenomics approach for discovery of ribosomal peptide natural products with blind modifications from microbial communities. Cell Systems, 9(6), 600-+.
O’Donoghue, A. J., Bibo-Verdugo, B., Miyamoto, Y., Wang, S. C., Yang, J. Z., Zuill, D. E., Matsuka, S., Jiang, Z. Z., Almaliti, J., Caffrey, C. R., Gerwick, W. H., & Eckmann, L. (2019). 20S proteasome as a drug target in Trichomonas vaginalis. Antimicrobial Agents and Chemotherapy, 63(11).
Bibo-Verdugo, B., Wang, S. C., Almaliti, J., Ta, A. P., Jiang, Z. Z., Wong, D. A., Lietz, C. B., Suzuki, B. M., El-Saldary, N., Hook, V., Salvesen, G. S., Gerwick, W. H., Caffrey, C. R., & O’Donoghue, A. J. (2019). The proteasome as a drug target in the metazoan pathogen, Schistosoma mansoni. Acs Infectious Diseases, 5(10), 1802–1812.
Boudreau, P. D., Miller, B. W., McCall, L. I., Almaliti, J., Reher, R., Hirata, K., Le, T., Siqueira-Neto, J. L., Hook, V., & Gerwick, W. H. (2019). Design of Gallinamide A analogs as potent inhibitors of the cysteine proteases human Cathepsin L and Trypanosoma cruzi Cruzain. Journal of Medicinal Chemistry, 62(20), 9026–9044.
Yu, H. B., Glukhov, E., Li, Y. Y., Iwasaki, A., Gerwick, L., Dorrestein, P. C., Jiao, B. H., & Gerwick, W. H. (2019). Cytotoxic microcolin lipopeptides from the marine cyanobacterium Moorea producens. Journal of Natural Products, 82(9), 2608–2619.
Moss, N. A., Seiler, G., Leao, T. F., Castro-Falcon, G., Gerwick, L., Hughes, C. C., & Gerwick, W. H. (2019). Nature’s combinatorial biosynthesis produces vatiamides A-F. Angewandte Chemie-International Edition, 58(27), 9027–9031.
Tayler, N. M., Boya, C. A., Herrera, L., Moy, J., Ng, M., Pineda, L., Almanza, A., Rosero, S., Coronado, L. M., Correa, R., Santamaria, R., Caballero, Z., Durant-Archibold, A. A., Currency, K. J. T., Balunas, M. J., Gerwick, W. H., Spadafora, A., Gutierrez, M., & SpadaforaId, C. (2019). Analysis of the antiparasitic and anticancer activity of the coconut palm (Cocos nucifera L. ARECACEAE) from the natural reserve of Punta Patino, Darien. PLOS ONE, 14(4).
Hou, X. M., Wang, C. Y., Gerwick, W. H., & Shao, C. L. (2019). Marine natural products as potential anti-tubercular agents. European Journal of Medicinal Chemistry, 165, 273–292.
Caro-Diaz, E. J. E., Valeriote, F. A., & Gerwick, W. H. (2019). Highly convergent total synthesis and assignment of absolute configuration of majusculamide D, a potent and selective cytotoxic metabolite from Moorea sp. Organic Letters, 21(3), 793–796.
Chen, H. M., Yang, R., Chen, J. J., Luo, Q. J., Cui, X. S., Yan, X. J., & Gerwick, W. H. (2019). 1-Octen-3-ol, a self-stimulating oxylipin messenger, can prime and induce defense of marine alga. Bmc Plant Biology, 19.
Almaliti, J., Miller, B., Pietraszkiewicz, H., Glukhov, E., Naman, C. B., Kline, T., Hanson, J., Li, X. F., Zhou, S. H., Valeriote, F. A., & Gerwick, W. H. (2019). Exploration of the carmaphycins as payloads in antibody drug conjugate anticancer agents. European Journal of Medicinal Chemistry, 161, 416–432.
McAlpine, J. B., Chen, S. N., Kutateladze, A., MacMillan, J. B., Appendino, G., Barison, A., Beniddir, M. A., Biavatti, M. W., Bluml, S., Boufridi, A., Butler, M. S., Capon, R. J., Choi, Y. H., Coppage, D., Crews, P., Crimmins, M. T., Csete, M., Dewapriya, P., Egan, J. M., … Pauli, G. F. (2019). The value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research. Natural Product Reports, 36(1), 35–107.
Choi, H., Engene, N., Byrum, T., Hwang, S., Oh, D. C., & Gerwick, W. H. (2019). Dragocins A-D, structurally intriguing cytotoxic metabolites from a Panamanian marine cyanobacterium. Organic Letters, 21(1), 266–270.
Ong, J. F. M., Goh, H. C., Lim, S. C., Pang, L. M., Chin, J. S. F., Tan, K. S., Liang, Z. X., Yang, L., Glukhov, E., Gerwick, W. H., & Tan, L. T. (2019). Integrated genomic and metabolomic approach to the discovery of potential anti-quorum sensing natural products from microbes associated with marine samples from Singapore. Marine Drugs, 17(1).
Ding, C. Y. G., Pang, L. M., Liang, Z. X., Goh, K. K. K., Glukhov, E., Gerwick, W. H., & Tan, L. T. (2018). MS/MS-based molecular networking approach for the detection of aplysiatoxin-related compounds in environmental marine cyanobacteria. Marine Drugs, 16(12).
Moss, N. A., Leao, T., Rankin, M. R., McCullough, T. M., Qu, P. P., Korobeynikov, A., Smith, J. L., Gerwick, L., & Gerwick, W. H. (2018). Ketoreductase domain dysfunction expands chemodiversity: Malyngamide biosynthesis in the cyanobacterium Okeania hirsuta. Acs Chemical Biology, 13(12), 3385–3395.
Skiba, M. A., Bivins, M. M., Schultz, J. R., Bernard, S. M., Fiers, W. D., Dan, Q. Y., Kulkarni, S., Wipf, P., Gerwick, W. H., Sherman, D. H., Aldrich, C. C., & Smith, J. L. (2018). Structural basis of polyketide synthase o-methylation. Acs Chemical Biology, 13(12), 3221–3228.
Via, C. W., Glukhov, E., Costa, S., Zimba, P. V., Moeller, P. D. R., Gerwick, W. H., & Bertin, M. J. (2018). The metabolome of a cyanobacterial bloom visualized by MS/MS-based molecular networking reveals new neurotoxic smenamide analogs (C, D, and E). Frontiers in Chemistry, 6.
Huang, Q. L., Chen, J., Zhang, W. J., Zhou, B. P., Zhang, C. L., Gerwick, W. H., & Cao, Z. Y. (2018). Alkaloids from Corydalis decumbens suppress neuronal excitability in primary cultures of mouse neocortical neurons. Phytochemistry, 150, 85–92.
O’Rourke, A., Kremb, S., Duggan, B. M., Sioud, S., Kharbatia, N., Raji, M., Emwas, A. H., Gerwick, W. H., & Voolstra, C. R. (2018). Identification of a 3-Alkylpyridinium Compound from the Red Sea Sponge Amphimedon chloros with In Vitro Inhibitory Activity against the West Nile Virus NS3 Protease. Molecules, 23(6).
Skiba, M. A., Sikkema, A. P., Moss, N. A., Lowell, A. N., Su, M., Sturgis, R. M., Gerwick, L., Gerwick, W. H., Sherman, D. H., & Smith, J. L. (2018). Biosynthesis of t-Butyl in apratoxin A: functional analysis and architecture of a PKS loading module. Acs Chemical Biology, 13(6), 1640–1650.
Wang, J. L., Zheng, J. C., Huang, C. H., Zhao, J. Y., Lin, J. J., Zhou, X. Z., Naman, C. B., Wang, N., Gerwick, W. H., Wang, Q. W., Yan, X. J., Cui, W., & He, S. (2018). Eckmaxol, a phlorotannin extracted from ecklonia maxima, produces anti-ss-amyloid oligomer neuroprotective effects possibly via directly acting on glycogen synthase kinase 3 ss. Acs Chemical Neuroscience, 9(6), 1349–1356.
Kristoffersen, V., Rama, T., Isaksson, J., Andersen, J. H., Gerwick, W. H., & Hansen, E. (2018). Characterization of rhamnolipids produced by an Arctic marine bacterium from the Pseudomonas fluorescence group. Marine Drugs, 16(5).
Mascuch, S. J., Boudreau, P. D., Carland, T. M., Pierce, N. T., Olson, J., Hensler, M. E., Choi, H., Campanale, J., Hamdoun, A., Nizet, V., Gerwick, W. H., Gaasterland, T., & Gerwick, L. (2018). Marine natural product honaucin A attenuates inflammation by activating the Nrf2-ARE pathway. Journal of Natural Products, 81(3), 506–514.
Tao, Y. W., Li, P. L., Zhang, D. J., Glukhov, E., Gerwick, L., Zhang, C., Murray, T. F., & Gerwick, W. H. (2018). Samholides, swinholide-related metabolites from a marine cyanobacterium cf. Phormidium sp. Journal of Organic Chemistry, 83(6), 3034–3046.
Shao, C. L., Mou, X. F., Cao, F., Spadafora, C., Glukhov, E., Gerwick, L., Wang, C. Y., & Gerwick, W. H. (2018). Bastimolide B, an antimalarial 24-membered marine macrolide possessing a tert-butyl group. Journal of Natural Products, 81(1), 211–215.
Moss, N. A., Leao, T., Glukhov, E., Gerwick, L., & Gerwick, W. H. (2018). Collection, Culturing, and Genome Analyses of Tropical Marine Filamentous Benthic Cyanobacteria. In B. S. Moore (Ed.), Marine Enzymes and Specialized Metabolism, Pt A (Vol. 604, pp. 3–43). Elsevier Academic Press Inc.
Skiba, M. A., Sikkema, A. P., Moss, N. A., Tran, C. L., Sturgis, R. M., Gerwick, L., Gerwick, W. H., Sherman, D. H., & Smith, J. L. (2017). A mononuclear iron-dependent methyltransferase catalyzes initial steps in assembly of the apratoxin A polyketide starter unit. Acs Chemical Biology, 12(12), 3039–3048.