Publications – Zotero

Yoon, M. C., Solania, A., Jiang, Z. Z., Christy, M. P., Podvin, S., Mosier, C., Lietz, C. B., Ito, G., Gerwick, W. H., Wolan, D. W., Hook, G., O’Donoghue, A. J., & Hook, V. (2021). Selective neutral pH Inhibitor of Cathepsin B designed based on cleavage preferences at cytosolic and lysosomal pH conditions. Acs Chemical Biology, 16(9), 1628–1643. https://doi.org/10.1021/acschembio.1c00138
Iwasaki, A., Teranuma, K., Kurisawa, N., Rahmawati, Y., Jeelani, G., Nozaki, T., Gerwick, W. H., & Suenaga, K. (2021). First total synthesis and structure-activity relationship of iheyamide A, an antitrypanosomal linear peptide isolated from a Dapis sp. Marine cyanobacterium. Journal of Natural Products, 84(9), 2587–2593. https://doi.org/10.1021/acs.jnatprod.1c00792
Kim, H. W., Jeon, J. B., Zhang, M., Cho, H. M., Ryu, B., Lee, B. W., Gerwick, W. H., & Oh, W. K. (2021). SIRT1 Activation Enhancing 8,3 ’-Neolignans from the Twigs of Corylopsis coreana Uyeki. Plants-Basel, 10(8), 12. https://doi.org/10.3390/plants10081684
Demirkiran, O., Almaliti, J., Leao, T., Navarro, G., Byrum, T., Valeriote, F. A., Gerwick, L., & Gerwick, W. H. (2021). Portobelamides A and B and Caciqueamide, Cytotoxic Peptidic Natural Products from a Caldora sp. Marine Cyanobacterium. Journal of Natural Products, 84(8), 2081–2093. https://doi.org/10.1021/acs.jnatprod.0c01383
Taylor, K. S., Zhang, C., Glukhov, E., Gerwick, W. H., & Suyama, T. L. (2021). Total synthesis of laucysteinamide A, a monomeric congener of somocystinamide A. Journal of Natural Products, 84(3), 865–870. https://doi.org/10.1021/acs.jnatprod.0c01317
Li, L., Yang, M., Shrestha, S. K., Kim, H., Gerwick, W. H., & Soh, Y. (2021). Kalkitoxin reduces osteoclast formation and resorption and protects against inflammatory bone loss. International Journal of Molecular Sciences, 22(5). https://doi.org/10.3390/ijms22052303
Leber, C. A., Reyes, A. J., Biggs, J. S., & Gerwick, W. H. (2021). Cyanobacteria-shrimp colonies in the Mariana Islands. Aquatic Ecology. https://doi.org/10.1007/s10452-021-09837-6
Christy, M. P., Uekusa, Y., Gerwick, L., & Gerwick, W. H. (2021). Natural products with potential to treat RNA virus pathogens including SARS-CoV-2. Journal of Natural Products, 84(1), 161–182. https://doi.org/10.1021/acs.jnatprod.0c00968
Leao, T., Wang, M. X., Moss, N., da Silva, R., Sanders, J., Nurk, S., Gurevich, A., Humphrey, G., Reher, R., Zhu, Q. Y., Belda-Ferre, P., Glukhov, E., Whitner, S., Alexander, K. L., Rex, R., Pevzner, P., Dorrestein, P. C., Knight, R., Bandeira, N., … Gerwick, L. (2021). A multi-omics characterization of the natural product potential of tropical filamentous marine cyanobacteria. Marine Drugs, 19(1). https://doi.org/10.3390/md19010020
Taton, A., Ecker, A., Diaz, B., Moss, N. A., Anderson, B., Reher, R., Leao, T. F., Simkovsky, R., Dorrestein, P. C., Gerwick, L., Gerwick, W. H., & Golden, J. W. (2020). Heterologous expression of cryptomaldamide in a cyanobacterial host. Acs Synthetic Biology, 9(12), 3364–3376. https://doi.org/10.1021/acssynbio.0c00431
Li, Y. Y., Naman, C. B., Alexander, K. L., Guan, H. S., & Gerwick, W. H. (2020). The chemistry, biochemistry and pharmacology of marine natural products from Leptolyngbya, a chemically endowed genus of cyanobacteria. Marine Drugs, 18(10). https://doi.org/10.3390/md18100508
Leber, C. A., Naman, C. B., Keller, L., Almaliti, J., Caro-Diaz, E. J. E., Glukhov, E., Joseph, V., Sajeevan, T. P., Reyes, A. J., Biggs, J. S., Li, T., Yuan, Y., He, S., Yan, X. J., & Gerwick, W. H. (2020). Applying a chemogeographic strategy for natural product discovery from the marine cyanobacterium Moorena bouillonii. Marine Drugs, 18(10). https://doi.org/10.3390/md18100515
Wold, C. W., Gerwick, W. H., Wangensteen, H., & Inngjerdingen, K. T. (2020). Bioactive triterpenoids and water-soluble melanin from Inonotus obliquus (Chaga) with immunomodulatory activity. Journal of Functional Foods, 71. https://doi.org/10.1016/j.jff.2020.104025
Yang, J. M., Liu, Y. Y., Yang, W. C., Ma, X. X., Nie, Y. Y., Glukhov, E., Gerwick, L., Gerwick, W. H., Lei, X. L., & Zhang, Y. (2020). An anti-inflammatory isoflavone from soybean inoculated with a marine fungusAspergillus terreusC23-3. Bioscience Biotechnology and Biochemistry, 84(8), 1546–1553. https://doi.org/10.1080/09168451.2020.1764838
Ndukwe, I. E., Wang, X., Lam, N. Y. S., Ermanis, K., Alexander, K. L., Bertin, M. J., Martin, G. E., Muir, G., Paterson, I., Britton, R., Goodman, J. M., Helfrich, E. J. N., Piel, J., Gerwick, W. H., & Williamson, R. T. (2020). Synergism of anisotropic and computational NMR methods reveals the likely configuration of phormidolide A. Chemical Communications, 56(55), 7565–7568. https://doi.org/10.1039/d0cc03055d
Sequeira, E., Pierce, M. L., Akasheh, D., Sellers, S., Gerwick, W. H., Baden, D. G., & Murray, T. F. (2020). Epicortical Brevetoxin Treatment Promotes Neural Repair and Functional Recovery after Ischemic Stroke. Marine Drugs, 18(7). https://doi.org/10.3390/md18070374
Keller, L., Siqueira-Neto, J. L., Souza, J. M., Eribez, K., LaMonte, G. M., Smith, J. E., & Gerwick, W. H. (2020). Palstimolide A: A complex polyhydroxy macrolide with antiparasitic activity. Molecules, 25(7). https://doi.org/10.3390/molecules25071604
Keller, L., Canuto, K. M., Liu, C. X., Suzuki, B. M., Almaliti, J., Sikandar, A., Naman, C. B., Glukhov, E., Luo, D. M., Duggan, B. M., Luesch, H., Koehnke, J., O’Donoghue, A. J., & Gerwick, W. H. (2020). Tutuilamides A-C: Vinyl-chloride-containing cyclodepsipeptides from marine cyanobacteria with potent elastase inhibitory properties. Acs Chemical Biology, 15(3), 751–757. https://doi.org/10.1021/acschembio.9b00992
Uranga, C. C., Arroyo, P., Duggan, B. M., Gerwick, W. H., & Edlunda, A. (2020). Commensal oral rothia mucilaginosa produces enterobactin, a metal-chelating siderophore. MSystems, 5(2). https://doi.org/10.1128/mSystems.00161-20
Li, Y. Y., Yu, H. B., Zhang, Y., Leao, T., Glukhov, E., Pierce, M. L., Zhang, C., Kim, H., Mao, H. H., Fang, F., Cottrell, G. W., Murray, T. F., Gerwick, L., Guan, H. S., & Gerwick, W. H. (2020). Pagoamide A, a cyclic depsipeptide isolated from a cultured marine chlorophyte, Derbesia sp., using MS/MS-based molecular networking. Journal of Natural Products, 83(3), 617–625. https://doi.org/10.1021/acs.jnatprod.9b01019
Reher, R., Kim, H. W., Zhang, C., Mao, H. H., Wang, M. X., Nothias, L. F., Caraballo-Rodriguez, A. M., Glukhov, E., Teke, B., Leao, T., Alexander, K. L., Duggan, B. M., Van Everbroeck, E. L., Dorrestein, P. C., Cottrell, G. W., & Gerwick, W. H. (2020). A convolutional neural network-based approach for the rapid annotation of molecularly diverse natural products. Journal of the American Chemical Society, 142(9), 4114–4120. https://doi.org/10.1021/jacs.9b13786
Skiba, M. A., Tran, C. L., Dan, Q. Y., Sikkema, A. P., Klaver, Z., Gerwick, W. H., Sherman, D. H., & Smith, J. L. (2020). Repurposing the GNAT fold in the initiation of polyketide biosynthesis. Structure, 28(1), 63-+. https://doi.org/10.1016/j.str.2019.11.004
Cao, L., Gurevich, A., Alexander, K. L., Naman, C. B., Leao, T., Glukhov, E., Luzzatto-Knaan, T., Vargas, F., Quinn, R., Bouslimani, A., Nothias, L. F., Singh, N. K., Sanders, J. G., Benitez, R. A. S., Thompson, L. R., Hamid, M. N., Morton, J. T., Mikheenko, A., Shlemov, A., … Mohimani, H. (2019). MetaMiner: A scalable peptidogenomics approach for discovery of ribosomal peptide natural products with blind modifications from microbial communities. Cell Systems, 9(6), 600-+. https://doi.org/10.1016/j.cels.2019.09.004
O’Donoghue, A. J., Bibo-Verdugo, B., Miyamoto, Y., Wang, S. C., Yang, J. Z., Zuill, D. E., Matsuka, S., Jiang, Z. Z., Almaliti, J., Caffrey, C. R., Gerwick, W. H., & Eckmann, L. (2019). 20S proteasome as a drug target in Trichomonas vaginalis. Antimicrobial Agents and Chemotherapy, 63(11). https://doi.org/10.1128/aac.00448-19
Bibo-Verdugo, B., Wang, S. C., Almaliti, J., Ta, A. P., Jiang, Z. Z., Wong, D. A., Lietz, C. B., Suzuki, B. M., El-Saldary, N., Hook, V., Salvesen, G. S., Gerwick, W. H., Caffrey, C. R., & O’Donoghue, A. J. (2019). The proteasome as a drug target in the metazoan pathogen, Schistosoma mansoni. Acs Infectious Diseases, 5(10), 1802–1812. https://doi.org/10.1021/acsinfecdis.9b00237
Boudreau, P. D., Miller, B. W., McCall, L. I., Almaliti, J., Reher, R., Hirata, K., Le, T., Siqueira-Neto, J. L., Hook, V., & Gerwick, W. H. (2019). Design of Gallinamide A analogs as potent inhibitors of the cysteine proteases human Cathepsin L and Trypanosoma cruzi Cruzain. Journal of Medicinal Chemistry, 62(20), 9026–9044. https://doi.org/10.1021/acs.jmedchem.9b00294
Yu, H. B., Glukhov, E., Li, Y. Y., Iwasaki, A., Gerwick, L., Dorrestein, P. C., Jiao, B. H., & Gerwick, W. H. (2019). Cytotoxic microcolin lipopeptides from the marine cyanobacterium Moorea producens. Journal of Natural Products, 82(9), 2608–2619. https://doi.org/10.1021/acs.jnatprod.9b00549
Moss, N. A., Seiler, G., Leao, T. F., Castro-Falcon, G., Gerwick, L., Hughes, C. C., & Gerwick, W. H. (2019). Nature’s combinatorial biosynthesis produces vatiamides A-F. Angewandte Chemie-International Edition, 58(27), 9027–9031. https://doi.org/10.1002/anie.201902571
Tayler, N. M., Boya, C. A., Herrera, L., Moy, J., Ng, M., Pineda, L., Almanza, A., Rosero, S., Coronado, L. M., Correa, R., Santamaria, R., Caballero, Z., Durant-Archibold, A. A., Currency, K. J. T., Balunas, M. J., Gerwick, W. H., Spadafora, A., Gutierrez, M., & SpadaforaId, C. (2019). Analysis of the antiparasitic and anticancer activity of the coconut palm (Cocos nucifera L. ARECACEAE) from the natural reserve of Punta Patino, Darien. PLOS ONE, 14(4). https://doi.org/10.1371/journal.pone.0214193
Hou, X. M., Wang, C. Y., Gerwick, W. H., & Shao, C. L. (2019). Marine natural products as potential anti-tubercular agents. European Journal of Medicinal Chemistry, 165, 273–292. https://doi.org/10.1016/j.ejmech.2019.01.026
Caro-Diaz, E. J. E., Valeriote, F. A., & Gerwick, W. H. (2019). Highly convergent total synthesis and assignment of absolute configuration of majusculamide D, a potent and selective cytotoxic metabolite from Moorea sp. Organic Letters, 21(3), 793–796. https://doi.org/10.1021/acs.orglett.8b04050
Chen, H. M., Yang, R., Chen, J. J., Luo, Q. J., Cui, X. S., Yan, X. J., & Gerwick, W. H. (2019). 1-Octen-3-ol, a self-stimulating oxylipin messenger, can prime and induce defense of marine alga. Bmc Plant Biology, 19. https://doi.org/10.1186/s12870-019-1642-0
Almaliti, J., Miller, B., Pietraszkiewicz, H., Glukhov, E., Naman, C. B., Kline, T., Hanson, J., Li, X. F., Zhou, S. H., Valeriote, F. A., & Gerwick, W. H. (2019). Exploration of the carmaphycins as payloads in antibody drug conjugate anticancer agents. European Journal of Medicinal Chemistry, 161, 416–432. https://doi.org/10.1016/j.ejmech.2018.10.024
McAlpine, J. B., Chen, S. N., Kutateladze, A., MacMillan, J. B., Appendino, G., Barison, A., Beniddir, M. A., Biavatti, M. W., Bluml, S., Boufridi, A., Butler, M. S., Capon, R. J., Choi, Y. H., Coppage, D., Crews, P., Crimmins, M. T., Csete, M., Dewapriya, P., Egan, J. M., … Pauli, G. F. (2019). The value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research. Natural Product Reports, 36(1), 35–107. https://doi.org/10.1039/c7np00064b
Choi, H., Engene, N., Byrum, T., Hwang, S., Oh, D. C., & Gerwick, W. H. (2019). Dragocins A-D, structurally intriguing cytotoxic metabolites from a Panamanian marine cyanobacterium. Organic Letters, 21(1), 266–270. https://doi.org/10.1021/acs.orglett.8b03712
Ong, J. F. M., Goh, H. C., Lim, S. C., Pang, L. M., Chin, J. S. F., Tan, K. S., Liang, Z. X., Yang, L., Glukhov, E., Gerwick, W. H., & Tan, L. T. (2019). Integrated genomic and metabolomic approach to the discovery of potential anti-quorum sensing natural products from microbes associated with marine samples from Singapore. Marine Drugs, 17(1). https://doi.org/10.3390/md17010072
Ding, C. Y. G., Pang, L. M., Liang, Z. X., Goh, K. K. K., Glukhov, E., Gerwick, W. H., & Tan, L. T. (2018). MS/MS-based molecular networking approach for the detection of aplysiatoxin-related compounds in environmental marine cyanobacteria. Marine Drugs, 16(12). https://doi.org/10.3390/md16120505
Moss, N. A., Leao, T., Rankin, M. R., McCullough, T. M., Qu, P. P., Korobeynikov, A., Smith, J. L., Gerwick, L., & Gerwick, W. H. (2018). Ketoreductase domain dysfunction expands chemodiversity: Malyngamide biosynthesis in the cyanobacterium Okeania hirsuta. Acs Chemical Biology, 13(12), 3385–3395. https://doi.org/10.1021/acschembio.8b00910
Skiba, M. A., Bivins, M. M., Schultz, J. R., Bernard, S. M., Fiers, W. D., Dan, Q. Y., Kulkarni, S., Wipf, P., Gerwick, W. H., Sherman, D. H., Aldrich, C. C., & Smith, J. L. (2018). Structural basis of polyketide synthase o-methylation. Acs Chemical Biology, 13(12), 3221–3228. https://doi.org/10.1021/acschembio.8b00687
Via, C. W., Glukhov, E., Costa, S., Zimba, P. V., Moeller, P. D. R., Gerwick, W. H., & Bertin, M. J. (2018). The metabolome of a cyanobacterial bloom visualized by MS/MS-based molecular networking reveals new neurotoxic smenamide analogs (C, D, and E). Frontiers in Chemistry, 6. https://doi.org/10.3389/fchem.2018.00316
Huang, Q. L., Chen, J., Zhang, W. J., Zhou, B. P., Zhang, C. L., Gerwick, W. H., & Cao, Z. Y. (2018). Alkaloids from Corydalis decumbens suppress neuronal excitability in primary cultures of mouse neocortical neurons. Phytochemistry, 150, 85–92. https://doi.org/10.1016/j.phytochem.2018.03.006
O’Rourke, A., Kremb, S., Duggan, B. M., Sioud, S., Kharbatia, N., Raji, M., Emwas, A. H., Gerwick, W. H., & Voolstra, C. R. (2018). Identification of a 3-Alkylpyridinium Compound from the Red Sea Sponge Amphimedon chloros with In Vitro Inhibitory Activity against the West Nile Virus NS3 Protease. Molecules, 23(6). https://doi.org/10.3390/molecules23061472
Skiba, M. A., Sikkema, A. P., Moss, N. A., Lowell, A. N., Su, M., Sturgis, R. M., Gerwick, L., Gerwick, W. H., Sherman, D. H., & Smith, J. L. (2018). Biosynthesis of t-Butyl in apratoxin A: functional analysis and architecture of a PKS loading module. Acs Chemical Biology, 13(6), 1640–1650. https://doi.org/10.1021/acschembio.8b00252
Wang, J. L., Zheng, J. C., Huang, C. H., Zhao, J. Y., Lin, J. J., Zhou, X. Z., Naman, C. B., Wang, N., Gerwick, W. H., Wang, Q. W., Yan, X. J., Cui, W., & He, S. (2018). Eckmaxol, a phlorotannin extracted from ecklonia maxima, produces anti-ss-amyloid oligomer neuroprotective effects possibly via directly acting on glycogen synthase kinase 3 ss. Acs Chemical Neuroscience, 9(6), 1349–1356. https://doi.org/10.1021/acschemneuro.7b00527
Kristoffersen, V., Rama, T., Isaksson, J., Andersen, J. H., Gerwick, W. H., & Hansen, E. (2018). Characterization of rhamnolipids produced by an Arctic marine bacterium from the Pseudomonas fluorescence group. Marine Drugs, 16(5). https://doi.org/10.3390/md16050163
Mascuch, S. J., Boudreau, P. D., Carland, T. M., Pierce, N. T., Olson, J., Hensler, M. E., Choi, H., Campanale, J., Hamdoun, A., Nizet, V., Gerwick, W. H., Gaasterland, T., & Gerwick, L. (2018). Marine natural product honaucin A attenuates inflammation by activating the Nrf2-ARE pathway. Journal of Natural Products, 81(3), 506–514. https://doi.org/10.1021/acs.jnatprod.7b00734
Tao, Y. W., Li, P. L., Zhang, D. J., Glukhov, E., Gerwick, L., Zhang, C., Murray, T. F., & Gerwick, W. H. (2018). Samholides, swinholide-related metabolites from a marine cyanobacterium cf. Phormidium sp. Journal of Organic Chemistry, 83(6), 3034–3046. https://doi.org/10.1021/acs.joc.8b00028
Shao, C. L., Mou, X. F., Cao, F., Spadafora, C., Glukhov, E., Gerwick, L., Wang, C. Y., & Gerwick, W. H. (2018). Bastimolide B, an antimalarial 24-membered marine macrolide possessing a tert-butyl group. Journal of Natural Products, 81(1), 211–215. https://doi.org/10.1021/acs.jnatprod.7b00917
Moss, N. A., Leao, T., Glukhov, E., Gerwick, L., & Gerwick, W. H. (2018). Collection, Culturing, and Genome Analyses of Tropical Marine Filamentous Benthic Cyanobacteria. In B. S. Moore (Ed.), Marine Enzymes and Specialized Metabolism, Pt A (Vol. 604, pp. 3–43). Elsevier Academic Press Inc.
Skiba, M. A., Sikkema, A. P., Moss, N. A., Tran, C. L., Sturgis, R. M., Gerwick, L., Gerwick, W. H., Sherman, D. H., & Smith, J. L. (2017). A mononuclear iron-dependent methyltransferase catalyzes initial steps in assembly of the apratoxin A polyketide starter unit. Acs Chemical Biology, 12(12), 3039–3048. https://doi.org/10.1021/acschembio.7b00746